The Evidence-Based Health Benefits Of Quercetin Supplements

The Evidence-Based Health Benefits Of Quercetin Supplements

Quercetin is one of the most abundantly consumed flavonoids in the human diet and is also one of the most researched phyto-nutrients from a scientific perspective.

Research has found quercetin, a flavonoid found in many fruits and vegetables has many potential therapeutic benefits including antioxidant, anti-inflammatory, anti-carcinogenic, antiviral activities, as well as the ability to inhibit lipid peroxidation, platelet aggregation and capillary permeability, and to stimulate mitochondrial biogenesis.

Studies have found a reduction in the risk of cardiovascular disease in subjects, who had a high dietary intake of flavonoids.

In this post we are going to take a look at the current scientific evidence on the potential health benefits of quercetin supplements.

Dietary Sources Of Quercetin

Some of the best food sources of Quercetin include onions, grapes, berries, cherries, broccoli, and citrus fruits.

The Evidence-Based Health Benefits Of Quercetin

Quercetin Reduces Blood Pressure

Quercetin Reduces Blood Pressure

Flavonoids such as Quercetin are proposed to support cardiovascular health through a variety of mechanisms.

One of these mechanisms is their anti-hypertensive properties and ability to reduce blood pressure. Hypertension is a common independent risk factor for cardiovascular disease.

Research has found Quercetin supplementation to have a statistically significant effect for reducing blood pressure.

A systematic review and meta-analysis of randomized controlled trials published in 2016 assessed the impact of Quercetin on blood pressure.

The systematic review and meta-analysis concluded:

The results of the meta-analysis showed a statistically significant effect of quercetin supplementation in the reduction of BP, possibly limited to, or greater with dosages of >500 mg/day. [1]

Quercetin Reduces Some Inflammatory Biomarkers

Quercetin Reduces Some Inflammatory Biomarkers

Research has found flavonoids such as Quercetin to exert potent anti-inflammatory properties and randomized controlled trials have found a significant reduction of circulating C-reactive protein (CRP) levels following quercetin supplementation.

A systematic review and meta-analysis of randomized controlled human trials published in 2017 assessed the effect of Quercetin on C-reactive protein (CRP).

Our findings showed a significant effect of quercetin supplementation on the C-reactive protein—especially at doses above 500 mg/day and in patients with CRP <3 mg/l. [2]

Another fairly recent meta-analysis of randomized controlled human trials published 2019 investigated the impact of quercetin on systemic levels of inflammation.

Subgroup analyses revealed a significant reduction in circulating CRP in participants with diagnosed diseases (SMD: –0.24, 95% CI: –0.49, 0.00) and IL-6 in females (SMD: –1.37, 95% CI: –1.93, –0.81), subjects with diagnosed diseases (SMD: –1.37, 95% CI: –1.93, –0.81) and with high-dose interventions (SMD: –0.69, 95% CI: –1.10, –0.38).

In conclusion, consumption of quercetin is a promising therapeutic strategy for chronic disease management. [3]

Individuals can now easily test inflammatory biomarkers such as hs-CRP(high‐sensitivity C‐reactive protein) from home using Forth with Life’s finger prick blood test kits. – hs-CRP Home Blood Test Kit

Quercetin May Improve Plasma Lipid Profiles

A systematic review and meta-analysis recently published in January 2020 summarized evidence of the effects of quercetin supplementation on plasma lipid profiles, blood pressure (BP), and glucose levels in humans by performing a meta-analysis of randomized controlled trials.

The systematic review and meta-analysis concluded:

Quercetin intake resulted in significantly decreased BP in humans. Moreover, participants who consumed quercetin for 8 weeks or more showed significantly changed levels of high-density lipoprotein cholesterol and triglycerides in trials with a parallel design. [4]

References

[1] Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

https://www.ncbi.nlm.nih.gov/pubmed/27405810

[2] Effects of supplementation with quercetin on plasma C-reactive protein concentrations: a systematic review and meta-analysis of randomized controlled trials

https://www.nature.com/articles/ejcn201755

[3] Impact of quercetin on systemic levels of inflammation: a meta-analysis of randomised controlled human trials

https://www.tandfonline.com/doi/abs/10.1080/09637486.2019.1627515?journalCode=iijf20

[4] Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels: a systematic review and meta-analysis

https://academic.oup.com/nutritionreviews/advance-article/doi/10.1093/nutrit/nuz071/5697189

The information in this article has not been evaluated by the FDA and should not be used to diagnose, cure or treat any disease, implied or otherwise.


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